Survival in adults with sickle cell disease in a high-income setting.
نویسندگان
چکیده
Molecular Haematology, Division of Cancer Studies, King’s College London, London, United Kingdom; Department of Haematological Medicine, King’s College Hospital National Health Service (NHS) Foundation Trust, London, United Kingdom; Division of Health and Social Care, King’s College London, London, United Kingdom; National Institute for Health Research (NIHR) Biomedical Research Centre, Guy’s and St. Thomas’ NHS Trust and King’s College London, London, United Kingdom; and NIHR Collaboration for Leadership in Applied Health Research and Care, King’s College Hospital NHS
منابع مشابه
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Abstract Background Prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in Khuzestan province. Sickle cell anemia and beta-thalassemia are predominantly common in Iranian Arabs. Pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. Periodic lung function asse...
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Hepatic dysfunction is a frequent manifestation in patients with sickle cell anemia. It is usually a multifactorial process. A rare benign form of extreme hyperbilirubinemia, presumably due to intrahepatic sickling, may be the cause. We report a 9 year old girl with sickle-thalassemia hemoglo binopathy, presenting with profound jaundice. Sickle cell disease is often mild in the Iranian popu...
متن کاملLevel of Hemoglobin F and Gg Gene Expression in Sickle Cell Disease and Their Association with Haplotype and XmnI Polymorphic Site in South of Iran
Background: Molecular genetic factors regulating hemoglobin F (Hb F) expression are important modifiers of the severity of sickle cell anemia (SS). Methods: The prevalence of XmnI polymorphic site, the Gg:Ag ratio and the Hb F level were determined using PCR-RFLP procedure, HPLC and alkaline denaturation method, respectively, in various haplotypes of 52 patients with SS, 18 patients with sickle...
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ورودعنوان ژورنال:
- Blood
دوره 128 10 شماره
صفحات -
تاریخ انتشار 2016